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Della Markson is searching for her son, a brilliant, nihilistic computer hacker who has invented an addictive computer game. Her former professor, Alex MacBride, an academic has-been desperately in need of a publication and a drink, is looking for the papers of an obscure, long-dead neurobiologist. As they stumble through a suburban landscape littered with broken marriages and blighted careers, they discover that their personal quests are of great interest to mysterious others, and that they have been drawn into a grand design full of wondrous possibilities and perilous meanings.